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Master Thesis

La Neuromyélite Optique de Devic à la Réunion

Abstract : Background : Optic Neuromyelitis is a rare inflammatory disease, mediated by pathogenic anti Aquaporin 4 antibodies affecting the Central Nervous System at the level of the optic nerve and the spinal cord. Its particularly severe clinical prognosis is variable depending on the populations described in the literature. The Réunion population has unique genetic and environmental characteristics. We have therefore described precisely the clinical and paraclinical particularities of these patients in order to better understand them and manage them locally Method : We carried out a retrospective descriptive study of Reunionese patients suffering from anti-Aquaporin 4 NMO according to the Wingerchuk 2015 criteria, having been followed for their disease between January 2010 and December 2018, corresponding to an average follow-up of 63.4 months. The search for anti-Aquaporin 4 antibodies was carried out by CBA or by Indirect Immunofluorescence. Results : The prevalence of “late-onset” forms was 44% including 12% of “very late-onset” forms, responsible for an average age of 48.4 years at the onset of the disease. Isolated initial optic neuritis represented 32% of the population, and 20% presented with binocular blindness at the end of follow-up. Isolated initial myelitis accounted for 60% of the population and 28% required at least the use of a wheelchair to get around. The myelitis was particularly extensive with an average of 9 medullary stages affected. Conclusion : The unique genetic and environmental conditions of the Reunionese population are at the origin of a particularly late and severe development of the disease.
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Master Thesis
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Submitted on : Friday, March 12, 2021 - 11:26:12 AM
Last modification on : Wednesday, November 3, 2021 - 4:29:23 AM
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  • HAL Id : dumas-03167602, version 1


Victor Cuvier. La Neuromyélite Optique de Devic à la Réunion. Sciences du Vivant [q-bio]. 2020. ⟨dumas-03167602⟩



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