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Master Thesis

Prise en charge préventive et curative de l'ostéoradionécrose dans la sphère orale

Abstract : Some cancers of the upper aerodigestive tract are treated with radiation therapy. One of the possible complications of this radiation therapy is osteoradionecrosis. The physiopathological mechanisms and treatments thereof are disputed. Material and methods : A review of the literature was carried out in order to highlight the means of prevention and current management of osteoradionecrosis. Result : Prevention significantly reduced the occurrence of osteoradionecrosis following radiotherapy. Many treatment methods have been implemented over the past thirty years. Currently, the gold standard treatment, once it has been diagnosed, is the combination of the PENTOCLO protocol with curative surgery. Discussion : The real efficacy of PENTOCLO has not been demonstrated despite excellent healing results. More randomized studies with larger study groups are needed.
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Submitted on : Tuesday, April 13, 2021 - 2:06:15 PM
Last modification on : Thursday, May 13, 2021 - 3:18:15 AM
Long-term archiving on: : Wednesday, July 14, 2021 - 6:34:52 PM


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  • HAL Id : dumas-03197013, version 1



Adrien Rougier. Prise en charge préventive et curative de l'ostéoradionécrose dans la sphère orale. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03197013⟩



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