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Master Thesis

Atteintes microcirculatoires de la thrombocytémie essentielle

Abstract : Introduction: essential thrombocythemia (ET) is the most common BCR-ABL negative myeloproliferative neoplasia. Its prognosis and management depend on the occurrence of thrombotic and haemorrhagic complications and its secondary myeloid transformation. Recent data suggest that microcirculatory manifestations at diagnosis could predict major thrombosis in essential thrombocythemia. Outcome: Does the occurrence of ET complications differ in a population with microcirculatory disorders when diagnosed with essential thrombocythemia? Patients and methods: longitudinal, retrospective, single-center observational study of patients with essential thrombocythemia whose diagnosis and follow-up was carried out at the Bordeaux University Hospital between January 2009 and June 2020. Results: 292 patients were included in the study, 54 of whom had microcirculatory disorders. 51 subjects were excluded from the study. No significant difference was observed in the occurrence of a thrombotic event at diagnosis as well as during follow-up (P = 0.86). There is no significant difference in the risk of secondary transformation to myelofibrosis AND / OR acute leukemia (P = 0.42) Discussion/conclusion: microcirculatory disorders are frequent manifestations of essential thrombocythemia. They define a phenotype of characteristic patients: more symptomatic, younger too. Their prognosis in terms of thrombotic complications and secondary transformation is comparable to the known data for essential thrombocythemia.
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Submitted on : Wednesday, November 10, 2021 - 4:45:36 PM
Last modification on : Thursday, December 16, 2021 - 3:54:17 AM
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  • HAL Id : dumas-03424991, version 1



Simon Moura. Atteintes microcirculatoires de la thrombocytémie essentielle. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03424991⟩



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